Compositions and Methods for inducing Immune Response Against Staphylococcus Aureus Causing Bovine Mastitis
Description:
Background
Bovine mastitis is a significant economic burden in the U.S. dairy industry estimating $2 billion loss annually. Bovine mastitis caused by Staphylococcus aureus is highly contagious, resistant to many antibiotics, and often resulted in loss of gland function. Many bovine mastitis vaccines for Staphylococcus aureus have used inactivated whole cell bacterium antigens to induce immune response to bacterial surface molecules involving colonization. However, most of these vaccines showed limited efficacy to prevent clinical bovine mastitis by S. aureus.
Technology Overview
Researchers from Mississippi State University and Animal and Plant Quarantine Agency hypothesized that bovine mastitis clinical symptoms by S. aureus are mainly induced by secreted toxins. Thus, it is necessary to induce protective/neutralizing immunity against secreted toxins. We have selected the most conserved secreted toxins in bovine mastitis, tested their role in bovine mastitis using knock out strain, generated recombinant toxoid proteins to prevent side effects, and demonstrated protective effects of vaccinating with recombinant toxoid antigens in mice and lactating dairy.
Applications
This treatment has potential application in veterinary medicine.
Patents
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