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Compositions and Methods for inducing Immune Response Against Staphylococcus Aureus Causing Bovine Mastitis

Published: 2/4/2025

Inventor(s): Keun Seok Seo, Dong Chan Moon

Background Bovine mastitis is a significant economic burden in the U.S. dairy industry estimating $2 billion loss annually. Bovine mastitis caused by Staphylococcus aureus is highly contagious, resistant to many antibiotics, and often resulted in loss of gland function. Many bovine mastitis vaccines for Staphylococcus aureus have used inactivated whole...

The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses

Published: 9/6/2024

Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen

Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...

Increased Expression of Hyperpolarization-activated Cyclic Nucleotidgated Channel 4 (HCN4) in Airway Muscle During Naturally Occuring Asthma-like Disease Directs Pharmacologic Modulation of Funny Current Pathways to Modify Bronchial Tone...

Published: 9/9/2024

Inventor(s): Cyprianna Swiderski, Courtney Hunter

TREM1, HMBGB1 and PGLYRP1 Antagonism: Therapeutics for Severe and Neutrophilic Asthma in Horses and Humans Overview of Technology Therapeutics for severe and neutrophilic asthma in horses and humans Background of Technology HMBGI signaling, TREM1 expression and signaling and PGLYRP1 expression are all increased in the lung biopsies of horses with...