Search Results - pharma 4 Results Sort By: Published Date Updated Date Title ID Descending Ascending The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses Published: 9/6/2024 Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon... A Method for Targeting Nanoparticles to Bacterial Biofilm Infections using Bacterial Surface Proteins Published: 10/2/2024 Inventor(s): Nicholas Fitzkee, Dhanush Amarasekara Background Biofilm‑related infections are associated with high mortality and morbidity, combined with increased hospital stays and overall treatment costs. Traditional antibiotics play an essential role in controlling biofilms; however, they are becoming less effective due to the emergence of drug‑resistant bacterial strains. The need to treat biofilms... Increased Expression of Hyperpolarization-activated Cyclic Nucleotidgated Channel 4 (HCN4) in Airway Muscle During Naturally Occuring Asthma-like Disease Directs Pharmacologic Modulation of Funny Current Pathways to Modify Bronchial Tone... Published: 9/9/2024 Inventor(s): Cyprianna Swiderski, Courtney Hunter TREM1, HMBGB1 and PGLYRP1 Antagonism: Therapeutics for Severe and Neutrophilic Asthma in Horses and Humans Overview of Technology Therapeutics for severe and neutrophilic asthma in horses and humans Background of Technology HMBGI signaling, TREM1 expression and signaling and PGLYRP1 expression are all increased in the lung biopsies of horses with... Synthesis of Optically Active Indoline Derivatives via Ruthenium (II)-Catalyzed Enantioselective C-H Functionalization Published: 7/26/2024 Inventor(s): Xin Cui, Zhong-Yuan Li, Chaminda Lakmal Hetti Handi Overview of Technology Provides a cost-effective, easy preparation, versatile and distinct reactivity for customization of the 4-formyl indoline derivatives Background This novel technology allows for some customization of the RU(II)-catalyzed method during asymmetric synthesis. Using the 4-formylindoline derivative (compound based on the indole...