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The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses

Published: 9/6/2024

Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen

Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...

Reagents, Devices, and Accessories for Kinetic Fluorogenic Chemical Quantification

Published: 11/4/2024

Inventor(s): Dongmao Zhang, Max Wamsley

Background Kinetic chromogenic (CG) and fluorogenic (FG) quantification deduces analyte concentration based on the reaction rate between the CG/FG probe and its targeted molecule. Little progress has been made in the past half century in either the theory or the applications of the kinetic spectroscopic quantification methods. Current kinetic CG/FG...

Mobile Markerless Motion Capture for Movement Data Collection in All Environments

Published: 12/6/2024

Inventor(s): Reuben Burch, Michael Thompson, Charles Freeman, Anthony Luczak, John Middleton, Harish Chander, David Saucier, John Ball

Overview of Technology Mobile markerless motion capture is a technology that collects biomechanical data by using drones and cameras which are synced to capture human or animal movement. Background Mobile markerless motion capture is the future of human performance data collection outside of the laboratory. Currently, Markered motion capture is considered...

Thienylpiperidine donor NIR I &II xanthene-based dye for imaging

Published: 9/5/2024

Inventor(s): Chathuranga Rathnamalala, Colleen Scott

Overview of Technology NIR Dyes that are highly stable, prepared by short and synthetic routes Background Very few Xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance greater than 600 nm exist. The few that exist are difficult to access, which require long and tedious synthetic steps. Photoacoustic tomography is a biomedical...

Increased Expression of Hyperpolarization-activated Cyclic Nucleotidgated Channel 4 (HCN4) in Airway Muscle During Naturally Occuring Asthma-like Disease Directs Pharmacologic Modulation of Funny Current Pathways to Modify Bronchial Tone...

Published: 9/9/2024

Inventor(s): Cyprianna Swiderski, Courtney Hunter

TREM1, HMBGB1 and PGLYRP1 Antagonism: Therapeutics for Severe and Neutrophilic Asthma in Horses and Humans Overview of Technology Therapeutics for severe and neutrophilic asthma in horses and humans Background of Technology HMBGI signaling, TREM1 expression and signaling and PGLYRP1 expression are all increased in the lung biopsies of horses with...