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Reagents, Devices, and Accessories for Kinetic Fluorogenic Chemical Quantification

Published: 11/4/2024

Inventor(s): Dongmao Zhang, Max Wamsley

Background Kinetic chromogenic (CG) and fluorogenic (FG) quantification deduces analyte concentration based on the reaction rate between the CG/FG probe and its targeted molecule. Little progress has been made in the past half century in either the theory or the applications of the kinetic spectroscopic quantification methods. Current kinetic CG/FG...

A Method for Targeting Nanoparticles to Bacterial Biofilm Infections using Bacterial Surface Proteins

Published: 10/2/2024

Inventor(s): Nicholas Fitzkee, Dhanush Amarasekara

Background Biofilm‑related infections are associated with high mortality and morbidity, combined with increased hospital stays and overall treatment costs. Traditional antibiotics play an essential role in controlling biofilms; however, they are becoming less effective due to the emergence of drug‑resistant bacterial strains. The need to treat biofilms...

Thienylpiperidine donor NIR I &II xanthene-based dye for imaging

Published: 9/5/2024

Inventor(s): Chathuranga Rathnamalala, Colleen Scott

Overview of Technology NIR Dyes that are highly stable, prepared by short and synthetic routes Background Very few Xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance greater than 600 nm exist. The few that exist are difficult to access, which require long and tedious synthetic steps. Photoacoustic tomography is a biomedical...