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The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses

Published: 9/6/2024

Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen

Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...

A Method for Targeting Nanoparticles to Bacterial Biofilm Infections using Bacterial Surface Proteins

Published: 10/2/2024

Inventor(s): Nicholas Fitzkee, Dhanush Amarasekara

Background Biofilm‑related infections are associated with high mortality and morbidity, combined with increased hospital stays and overall treatment costs. Traditional antibiotics play an essential role in controlling biofilms; however, they are becoming less effective due to the emergence of drug‑resistant bacterial strains. The need to treat biofilms...

mRNA Treatment to Induce Expression of Relaxin for Reproductive Applications in Animals and Humans

Published: 9/9/2024

Inventor(s): Peter Ryan, Amelia Woolums, Elmer King, Merrilee Thoresen, Federico Hoffmann

Background Female cattle and other animals, including humans, sometimes have trouble delivering their young (dystocia) at the time they are due because of inadequate relaxation or size of the mother's reproductive tract. Such situations can lead to difficult deliveries that may be harmful to the mother or the offspring. They may also require surgery...

Mobile Markerless Motion Capture for Movement Data Collection in All Environments

Published: 12/6/2024

Inventor(s): Reuben Burch, Michael Thompson, Charles Freeman, Anthony Luczak, John Middleton, Harish Chander, David Saucier, John Ball

Overview of Technology Mobile markerless motion capture is a technology that collects biomechanical data by using drones and cameras which are synced to capture human or animal movement. Background Mobile markerless motion capture is the future of human performance data collection outside of the laboratory. Currently, Markered motion capture is considered...

Increased Expression of Hyperpolarization-activated Cyclic Nucleotidgated Channel 4 (HCN4) in Airway Muscle During Naturally Occuring Asthma-like Disease Directs Pharmacologic Modulation of Funny Current Pathways to Modify Bronchial Tone...

Published: 9/9/2024

Inventor(s): Cyprianna Swiderski, Courtney Hunter

TREM1, HMBGB1 and PGLYRP1 Antagonism: Therapeutics for Severe and Neutrophilic Asthma in Horses and Humans Overview of Technology Therapeutics for severe and neutrophilic asthma in horses and humans Background of Technology HMBGI signaling, TREM1 expression and signaling and PGLYRP1 expression are all increased in the lung biopsies of horses with...